Tuesday, January 24, 2012

What the Funk? Terpenes Take off in Labs, Drug Companies, and Dispensaries

by David Downs
Tue, Jan 24, 2012 at 9:29 AM

Bay Area residents have yet another thing to be snobs about in 2012 as knowledge of “terpenes” — the building blocks that make up the unique smell of cannabis — begin to waft into the mainstream.

Drug companies are researching the therapeutic properties of these simple organic molecules, and at least two California medical cannabis labs have begun testing for their presence in dispensary weed. One lab in Davis even holds routine smelling classes.

SPARC Sungrown Pineapple Thais thick syrupy tropical fruit smell comes from its terpenes
  • David Downs
  • SPARC Sungrown Pineapple Thai's thick syrupy tropical fruit smell comes from its terpenes

Rick Pfrommer, manager at Harborside Health Center in Oakland, said that as head buyer for the popular dispensary, he has smelled countless numbers of bags and glass jars full of the sticky icky and that a lot of the odors he detects aren’t actually coming from the weed.

“You can smell everything from bat guano to heavy salt hydroponic fertilizers,” Pfrommer noted, during an interview inside Harborside’s buyer’s room, which is dominated by the examination counter, shelves of pot strain reference books, and expensive computers. Pfrommer has been selling ganja for about 25 years.

“You can smell chlorophyll, if a sample’s not cured well .... You can also smell molds," he continued. “Once you’ve smelled multiple thousands of samples of cannabis, when something is off, it's apparent that it's off, like, as soon as you crack the bag open."

Like a wine sommelier or a buyer for a boutique coffee roaster, Pfrommer smells each potential new addition to Harborside’s menu using a specific ritual.

First, he pops open a glass jar of coffee beans and takes a big sniff. Like ginger before sushi, coffee beans reset the palette, he said. Then he takes a big whiff from a sample cannabis bag, fishes out a single nug, cracks it open, and inhales deeply.

“All you really want to smell is the terpenes,” he said.

Diagram of a beta-caryophyllene molecule
  • Wikipedia
  • Diagram of a beta-caryophyllene molecule
According to Donald Land, a UC Davis chemistry professor who co-founded Halent Labs and conducts occasional smelling classes, “terpenes are a set of relatively simple organic molecules that are present in all living organisms; most of the flavors and aromas of plants comes from terpenes. The name 'terpene' is derived from the main ingredient in a certain type of pine pitch called turpentine. That piney smell that comes along with turpentine comes from terpenes. There are lots of others.”

Herbalists have recognized the power of terpenes for decades.

“Cannabis and other plants share a lot of the same terpenes, so terpenes have been legal for many decades,” Land noted. “There's been quite a bit of research on them in the US and abroad, including many well-documented medicinal effects.”

Damn you, hippie aromatherapists. According to a literature review by the medical cannabis journal O'Shaughnessy's:


limonene (also found in lemon) is an antidepressant and immune-stimulant in humans; alpha-pinene (also found in pine needles) is an anti-inflammatory, a bronchodilator, and a wide-spectrum antibiotic; nerolidol (also found in oranges) is a sedative; linalool (also found in lavender) has an anti-anxiety effect; and mrycene (also found in hops) is a sedative, a muscle relaxant, a sleep aid, and an anti-inflammatory.

Terpene comparison of two strains ToshOG and Dieblo
  • The Werc Shop
  • Terpene comparison of two strains ToshOG and Dieblo — bigger version here

Trainers teach drug dogs to hunt for beta-caryophyllene, a terpene in cannabis that also is an anti-inflammatory. Terpenes are also the chemical precursors to the euphoric ingredient in pot, THC, making them a proxy for potency.

Researchers like Ethan Russo, senior medical director at GW Pharmaceuticals, believe that terpenes contribute to the “entourage effect” that lies at the core of medicinal cannabis’ efficacy in treating nausea, inflammation, chronic pain, and more.

Efffects associated with cannabinoids and terpenes
  • Halent Labs
  • Effects associated with cannabinoids and terpenes — bigger version here

GW Pharmaceuticals has started growing terpene-only pot — sans THC — to better investigate the effects of terpenes, O'Shaughnessy’s reported. And unlike the THC pill Marinol, the new prescription throat spray Sativex contains THC, its therapeutic peer, CBD, and terpenes.

Terpenes also enable pot snobs to make outlandish yet credible claims that they smell chocolate, mango, diesel, or lavender in their bag. The five to ten main terpenes in cannabis have about 25 more rare peers, but cannabis has been found to contain more than 200 different types of them. The combinations are infinite. And the smells they create can have a big effect on medical cannabis users.

Major cannabis terpenes and their associated smells
  • Kushits.com
  • Major cannabis terpenes and their associated smells

“So many times, smell has trumped appearance when somebody is making a choice about which cannabis to buy,” said Pfrommer. “Somebody will smell a beautiful-looking sample and not like it at all, or they'll look at a sample that’s not quite attractive and smell it and it's just like — an instant hit.”

Popular strain OG Kush contains a mix of alpha-pinene, limonene, and perhaps myrcene to create its trademark “lemon, Pine-Sol funk,” Pfrommer said. Jack Herer’s beloved smell comes from sugary-pine terpene called terpineol.

Cannabis lab data from Halent Labs and The Werc Shop near Los Angeles is helping to elevate breeding to a science. It’s also giving patients a first-ever ingredients list for that dubious doobie, said Jeffrey Raber, director of The Werc Shop.

Down the line, Pfrommer envisions legal OG Kush deodorizers or Agent Orange floor cleaners.

“I think, along with CBD, terpenes are one of the two most exciting things going on in cannabis,” Pfrommer said. “We’re just scratching the surface now.”

And sniffing.

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