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Live music every night -- any band in town or on their way through with any kind of blues leaning at all will play at this little venue, more of a bistro than a dive. All-ages. Cover from $5-$20. Kitchen serves southern/Creole cuisine and closes at 11 p.m. Open Tues-Sat.

Folsom Street may not be the most picturesque destination in San Francisco, but that doesn’t stop musically inclined and hip thirtysomethings from hanging out at this popular cafe. Known for its unique combination as a cafe and Laundromat, Brainwash also features predominantly acoustic solo acts seven nights a week, as well as a Thursday comedy night. During the day, Brainwash attracts suit-and-tie types to informal business lunches over burgers and delicious french fries. At night, it’s a haven for young aspiring songwriters.

The 25-year-old comedy club in North Beach offers 400 seats along with a full menu and full bar. Many well-known comedians come through the stage at Cobb's; from Patton Oswalt to Norm McDonald and Pablo Francisco. There is usually a two-drink minimum. However, it's rarely enforced. Most acts are eighteen and over.

This neighborhood sports bar and restaurant dates back to the early-20th century, but has been the Connecticut Yankee since 1989. Located on the corner of Connecticut and 17th streets in Potrero Hill, it hosts live blues and funky jam bands about three or four nights a week. It has a dark, woody feel, perfect for seeking refuge on days when dreary fog blankets the city. A sports-lover's paradise, the bar has large-screen TVs, and serves brunch, lunch, and dinner.

In addition to a California/Mediterranean-inspired menu, the restuarant also hosts screenings of foreign and independent films in its covered courtyard.

Medjool is one of the swankier locales to pop up in the Mission District. Tall ceilings, slick wood floors (if you’re wearing stilettos, watch out), and three levels to lounge in make this an ideal spot for a fun night on the town. True to its Middle Eastern/North African theme, DJs spin “eclectic grooves” every Friday and Saturday night. For something truly unique, brave the fog on Medjool’s rooftop terrace, where the bar and boom-box sound system will keep you around all night.

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